Genetics

Epigenetic changes may explain chronic kidney disease

The research of physician-scientist Katalin Susztak, MD, PhD, associate professor of Medicine in the Renal Electrolyte and Hypertension Division, at the Perelman School of Medicine, University of Pennsylvania, strives to ...

Oncology & Cancer

Mutations of immune system found in breast cancers

Mutations in the genes that defend the body against cancer-related viruses and other infections may play a larger role in breast cancer than previously thought, according to a study at the University of Illinois at Chicago.

Genetics

Researching the roles of rare genetic variants in disease

As scientists work toward further personalizing medical treatment through genomics, heritability—the proportion of observed variation in a particular trait that can be attributed to inherited genetic factors—is key to ...

Genetics

On the lookout for the genes behind disease

Today's information age has provided the tools for biology to yield huge numbers of DNA sequences from many different species. Modern technology has made DNA sequencing simpler, less expensive and more reliable - with huge ...

Oncology & Cancer

No viral cause for breast cancer and brain tumors

A major study conducted at the Sahlgrenska Academy has now disproved theories of a viral cause for breast cancer and the brain tumour, glioblastoma. The study, which was based on over seven billion DNA sequences and which ...

Genetics

New survey of DNA alterations could aid search for cancer genes

Scanning the DNA of nearly 5,000 tumor samples, a team led by scientists at Dana-Farber Cancer Institute and the Broad Institute has identified 140 regions of scrambled genetic code believed to contain many undiscovered cancer ...

Genetics

Lifestyle influences metabolism via DNA methylation

An unhealthy lifestyle leaves traces in the DNA. These may have specific effects on metabolism, causing organ damage or disease. Scientists of Helmholtz Zentrum München have now identified 28 DNA alterations associated with ...

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