Medical research

Can toxicity of a DNA drug be predicted and minimized?

New classes of therapeutic antisense oligonucleotides can have toxic effects on the liver. A novel machine learning-based approach used to predict the hepatotoxic potential of an antisense drug based on its chemical sequence ...

Genetics

Skin cell defect is surprising allergy trigger

In a new study published in Nature Genetics, Northwestern Medicine and Tel Aviv University scientists have found that a structural defect in skin cells can contribute to allergy development, including skin and food allergies, ...

Genetics

Homing in on developmental epigenetics

Germ cells have unique molecular features that enable them to perform the important task of transmitting genetic information to the next generation. During development from their embryonic primordial state, germ cells are ...

Diseases, Conditions, Syndromes

MERS virus discovered in bat near site of outbreak in Saudi Arabia

A 100% genetic match for Middle East Respiratory Syndrome (MERS) has been discovered in an insect-eating bat in close proximity to the first known case of the disease in Saudi Arabia. The discovery points to the likely animal ...

Alzheimer's disease & dementia

A genetic answer to the Alzheimer's riddle?

What if we could pinpoint a hereditary cause for Alzheimer's, and intervene to reduce the risk of the disease? We may be closer to that goal, thanks to a team at the University of Kentucky. Researchers affiliated with the ...

Genetics

Researchers extend human epigenomic map

Ten years ago, scientists announced the end of the Human Genome Project, the international attempt to learn which combination of four nucleotides—adenine, thymine, cytosine, and guanine—is unique to homo sapien DNA. This ...

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