An enzyme that has been identified as instrumental in the progression of many types of cancer is meeting its match in inhibitors synthesized and evaluated by University of Colorado (CU) Cancer Center researchers.
Apr 7, 2022
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Whitehead Institute scientists have determined that master transcription factors determine the genes regulated by key signaling pathways. In this way, signaling pathways are targeted to genes that are most relevant to each ...
Oct 27, 2011
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Malignant melanoma is a highly aggressive and notoriously chemoresistant form of cancer. In a new paper, Ohanna et al. reveal that anti-melanoma drugs may, paradoxically, induce a senescence-associated secretory profile ("secretome") ...
Jun 6, 2011
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There are roughly 20,000 genes and thousands of other regulatory "elements" stored within the three billion letters of the human genome. Genes encode information that is used to create proteins, while other genomic elements ...
Nov 10, 2014
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(Medical Xpress)—Researchers at the University of Illinois have identified biomarkers that can be used to determine ovarian cancer survival and recurrence, and have shown how these biomarkers interact with each other to ...
Apr 30, 2013
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A pioneering report of genome-wide gene expression in autism spectrum disorders (ASDs) finds genetic changes that help explain why one person has an ASD and another does not. The study, published by Cell Press on June 21 ...
Jun 21, 2012
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Inside embryonic cells, specific proteins control the rate at which genetic information is transcribed from DNA to messenger RNA—a crucial regulatory step before proteins are created. Then, organs develop and hopefully ...
Apr 27, 2022
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Cancer is a complex disease and only thanks to advances in genomic techniques have researchers begun to understand, at a cellular and molecular level, the mechanisms which are disrupted in cancer cells. This knowledge is ...
Nov 22, 2012
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A team led by researchers at UT Southwestern Medical Center has developed deep learning models to identify a simple set of rules that govern the activity of promoters—regions of DNA that initiate the process by which genes ...
May 14, 2024
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Researchers in human genetics have known that long nucleotide repeats in DNA lead to instability of the genome and ultimately to human hereditary diseases such Freidreich's ataxia and Huntington's disease.
Nov 25, 2014
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