A new study published in Cell Reports found that a transcription factor called Slug serves as "command central" for determining breast stem cell health, regulating both stem cell activity and repair of DNA damage. The research ...
Jul 16, 2019
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People with Rett Syndrome, a rare and debilitating neurodevelopmental disorder, exhibit many autism-like traits. Now researchers at MIT have identified a protein that plays an important role in the disorder. The researchers ...
Jul 25, 2016
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A new genetic clue discovered by a team co-led by a researcher at the Perelman School of Medicine at the University of Pennsylvania is shedding light on the functions of the mysterious "long non-coding RNAs" (lncRNAs). These ...
Apr 7, 2016
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For years, scientists have struggled to find a way to block a protein known to play an important role in many cancers. The protein, STAT3, acts as a transcription factor—it performs the crucial task of helping convert DNA ...
Nov 19, 2015
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Researchers in human genetics have known that long nucleotide repeats in DNA lead to instability of the genome and ultimately to human hereditary diseases such Freidreich's ataxia and Huntington's disease.
Nov 25, 2014
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There are roughly 20,000 genes and thousands of other regulatory "elements" stored within the three billion letters of the human genome. Genes encode information that is used to create proteins, while other genomic elements ...
Nov 10, 2014
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Scientists have known for decades that cancer can be caused by genetic mutations, but more recently they have discovered that chemical modifications of a gene can also contribute to cancer. These alterations, known as epigenetic ...
Aug 12, 2014
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Twelve years ago, UNC School of Medicine researcher Brian Strahl, PhD, found that a protein called Set2 plays a role in how yeast genes are expressed – specifically how DNA gets transcribed into messenger RNA. Now his lab ...
Jun 9, 2014
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The same protein tells beta cells in the pancreas to stop making insulin and then to self-destruct as diabetes worsens, according to a University of Alabama at Birmingham (UAB) study published online today in the journal ...
Aug 26, 2013
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Researchers have probed deep into the cell's genome, beyond the basic genetic code, to begin learning the "grammar" that helps determine whether or not a gene gets switched on to make the protein it encodes.
Aug 12, 2013
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