In one of the largest studies of its kind, researchers used CRISPR technology to disrupt every gene in over 300 cancer models from 30 cancer types and discover thousands of key genes essential for cancer's survival. The team, ...
Apr 10, 2019
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115
For people with alcohol use disorder (AUD), there is a constant, vicious cycle between changes to the brain and changes to behavior. AUD can alter signaling pathways in the brain; in turn, those changes can exacerbate drinking.
Mar 6, 2023
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1026
Two doses of psilocybin, a compound found in psychedelic mushrooms, reduces heavy drinking by 83% on average among heavy drinkers when combined with psychotherapy, a new study shows. Led by researchers at NYU Grossman School ...
Aug 24, 2022
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365
When a heavy alcohol drinker tries to take a night off, their body protests with shaky hands, heart palpitations, anxiety and headaches. These acute symptoms of alcohol withdrawal—but even more so the enduring emotional ...
Mar 22, 2022
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96
Lonely, older adults are nearly twice as likely to use opioids to ease pain and two-and-a-half times more likely to use sedatives and anti-anxiety medications, putting themselves at risk for drug dependency, impaired attention, ...
Jul 26, 2021
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496
Most cancer drugs that target specific genetic mutations are designed for adult cancers rather than those in children, partly because pediatric cancers have fewer mutations. To look for more ways to target childhood cancers, ...
Mar 23, 2021
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222
A human genomics study led by two Yale Department of Psychiatry researchers identified specific genetic regions that link opioid exposure and dependence to neuropsychiatric traits like risk-taking behaviors, alcohol abuse, ...
Mar 24, 2020
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163
Approximately one-quarter of patients who are prescribed opioids for chronic pain misuse them, with five to 10 percent developing an opioid use disorder or addiction. In a new study, published Jan. 14, 2020 in PNAS, researchers ...
Jan 24, 2020
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261
A comprehensive map of genes necessary for cancer survival is one step closer, following the validation of the two largest CRISPR-Cas9 genetic screens in 725 cancer models, across 25 different cancer types. Scientists at ...
Dec 20, 2019
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56
Living alone is positively associated with common mental disorders, regardless of age and sex, according to a study published May 1, 2019 in the open-access journal PLOS ONE by Louis Jacob from University of Versailles Saint-Quentin-en-Yvelines, ...
May 1, 2019
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