Researchers have identified a new protein involved in the development of drug resistance in breast cancer which could be a target for new treatments, they report today in the journal Nature Medicine.
May 22, 2011
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A research team led by the University of California, Irvine has discovered the key role that the APOBEC3A and APOBEC3B enzymes play in driving cancer mutations by modifying the DNA in tumor genomes, offering potential new ...
Mar 19, 2024
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Mutations in a genetic region that regulates RNA stability could influence prostate cancer outcomes and drug resistance, according to new work from scientists at Fred Hutchinson Cancer Center published in Cell Reports.
Aug 7, 2023
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More than 70 FDA-approved cancer drugs are kinase inhibitors, which work by blocking kinases—enzymes that add phosphate groups to molecules in the cell—and preventing the chemical activity necessary for signaling and ...
Feb 13, 2023
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Imatinib, better known as Gleevec, was hailed as a "miracle" cancer drug when it entered the market in the early 2000s. Though it has been highly successful at treating early-stage chronic myeloid leukemia (CML)—a rare ...
Jun 1, 2022
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To many, tuberculosis (TB) may seem like a disease from a bygone era. But it still claims more than one million lives every year. And the problem is growing worse as Mycobacterium tuberculosis, the pathogen that causes TB, ...
May 9, 2022
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An antiviral drug used to treat SARS-CoV-2 remains effective against the newest variants of the evolving virus, according to Rutgers researchers.
Mar 18, 2022
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While gene mutations can lead to drug resistance, researchers in the Perelman School of Medicine at the University of Pennsylvania have identified an important, non-genetic adaptation that could also drive resistance to targeted ...
Mar 1, 2022
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Scientists have spotted signs of 'pre-resistance' in bacteria for the first time—signs that particular bacteria are likely to become resistant to antibiotics in the future—in a new study led by UCL and Great Ormond Street ...
Dec 15, 2021
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A new study led by University of California, Irvine (UCI) researchers identifies two ways in which APOBEC3A— a vital enzyme that is responsible for genetic changes resulting in a variety of cancers while protecting our ...
Aug 13, 2021
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