Medical research

Researchers discover why drug for severe COPD becomes less effective

Roflumilast, a drug recently approved in the United States to treat severe chronic obstructive pulmonary disease (COPD), increases the production of a protein that causes inflammation, which possibly results in patients developing ...

Medical research

Researchers uncover a new role of 'moonlighting' proteins

Although known to regulate fundamental cellular processes in humans, including cell growth, division and programmed cell death, the protein group known as chloride intracellular channel (CLIC) proteins is yet to be fully ...

Medical research

Loss of essential blood cell gene leads to anemia

Researchers at Brigham and Women's Hospital (BWH) have discovered a new gene that regulates hemoglobin synthesis during red blood cell formation. The findings advance the biomedical community's understanding and treatment ...

Diseases, Conditions, Syndromes

COVID-19 antibody discovery could explain long COVID

UVA Health researchers have discovered a potential explanation for some of the most perplexing mysteries of COVID-19 and long COVID. The surprising findings could lead to new treatments for the difficult acute effects of ...

Medical research

Defining the role of HDAC6 in regulating heart stiffness

Researchers at the University of Colorado School of Medicine have discovered an enzyme that regulates heart stiffness, setting the stage for developing novel treatments for heart failure.

Oncology & Cancer

New therapeutic target for hematologic malignancies identified

Inhibition of Ubiquitin Specific Peptidase 47 (USP47) was identified as a novel therapeutic target for hematologic malignancies bearing mutant oncoprotein EZH2, according to scientists from the Hefei Institutes of Physical ...

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