A large team of researchers from Denali Therapeutics, working with colleagues from multiple entities in the U.S. and one in Canada, has found that a LRRK2 inhibitor called DNL201 showed no ill effects to volunteers in a clinical ...
(Medical Xpress) -- Mayo Clinic researchers have discovered two mutations responsible for a devastating neurological condition they first identified 15 years ago. The researchers say their study -- appearing in Nature Genetics ...
May 1, 2011
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Cancer spreads throughout the human body in cunning, almost militaristic, ways. For example, it can manipulate our genetic make-up, take over specific cell-to-cell signaling processes, and mutate key enzymes to promote tumor ...
Jul 3, 2023
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The body's innate immune system, active from birth, is the first line of defense against viruses and other pathogens that cause disease. Using vaccination as an example, after receiving a vaccine, pain, redness, or swelling ...
May 25, 2022
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Nearly two million Americans have type 1 diabetes, a condition in which the body does not produce enough insulin to effectively manage blood sugar, leading to high blood sugar levels, or hyperglycemia. Persistent hyperglycemia ...
Mar 8, 2022
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A new combination of drugs could fix the broken lysosomal enzyme pathway in Parkinson's disease-afflicted brain cells, according to a Northwestern Medicine study published in Neuron.
Nov 24, 2021
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As many expectant mothers know, getting enough folate is key to avoiding neural tube defects in the baby during pregnancy. But for the individuals who carry certain genetic variants, dealing with folate deficiency can be ...
Jul 1, 2021
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The human body is constantly exposed to various environmental actors, from viruses to bacteria to fungi, but most of these microbial organisms provoke little or no response from our skin, which is charged with monitoring ...
May 21, 2021
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Carnosine and its precursor beta-alanine increase muscle strength, and have recently become extremely popular as dietary supplements in competitive sports. Researchers at University of Bergen, Norway, have recently discovered ...
Aug 5, 2020
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A drug used to treat and prevent HIV/AIDS is showing promise as a potential therapy for Alzheimer's disease, and Vanderbilt University biochemist F. Peter Guengerich, Ph.D., is aiding efforts to make this approach to improving ...
Dec 16, 2019
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