Researchers have uncovered mutations in the phosphatase Wip1 that enable cancer cells to foil the tumor suppressor p53, according to a study in The Journal of Cell Biology. The results could provide a new target for the treatment ...
May 6, 2013
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Researchers at the National Institutes of Health detected abnormal proteins in the spinal fluid of people with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), which could help improve diagnosis of these ...
Jan 31, 2024
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This first-in-human study of golodirsen showed its long-term safety and biologic activity in patients with Duchenne Muscular Dystrophy (DMD). The approved exon-skipping therapy is designed to enable the production of functional ...
Nov 30, 2021
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A Phase II clinical trial of poziotinib for non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 20 mutations, led by researchers at The University of Texas MD Anderson Cancer Center, found ...
Jul 11, 2022
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The powerful US Food and Drug Administration (FDA) has given the green light to a drug developed by WA researchers Sue Fletcher and Steve Wilton for treating Duchenne muscular dystrophy.
Sep 21, 2016
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A study published by IRB Barcelona in Nature Genetics demonstrates that the error (mutation) surveillance and repair system shows greater efficiency in the protein-coding regions of genes.
Nov 7, 2017
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A group of Ludwig Maximilian University scientists led by Eckhard Wolf has developed a porcine DMD model with a mutation that mimics the hallmarks of the human disease but develops them in an accelerated mode. The study is ...
Jul 13, 2023
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Nature Review Genetics has highlighted work by Milner Centre PhD student XianMing Wu.
Nov 26, 2015
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EGFR is a common genetic target in lung cancer, but not all EGFR mutations are created equal. Patients with a type of EGFR anomaly called an "EGFR exon 20 insertion" often fail to respond to existing drugs targeting EGFR. ...
Oct 24, 2017
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A recent large cohort study, conducted jointly by researchers from BGI Genomics and Nanjing Women and Children's Healthcare Hospital, implemented a self-developed prenatal screening strategy to effectively identify and classify ...
Jul 17, 2024
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