Fibroblasts build and maintain the extracellular matrix, or physical scaffolding for cells, in the connective tissues within the body. It is believed that cancerous tumors can recruit nearby fibroblasts and use them to promote ...
22 hours ago
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Researchers from Kyushu University have found how a single mechanosensitive protein induces the process that thickens and scars tissue, known as fibrosis. The protein, called VGLL3, was shown to contribute to fibrosis in ...
Mar 22, 2023
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A new research paper, titled "Senescence-associated exosomes transfer miRNA-induced fibrosis to neighboring cells," was published in Aging.
Mar 17, 2023
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Increasingly dense cell clusters in growing tumors convert blood vessels into fiber-filled channels. This makes immune cells less effective, as findings by researchers from ETH Zurich and the University of Strasbourg suggest. ...
Mar 17, 2023
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CÚRAM SFI Research Centre for Medical Devices researchers have published in Nature Communications a key study establishing a new pre-clinical model to develop clinically relevant treatments for heart attacks.
Feb 24, 2023
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DNA can help to stimulate bone healing in a localized and targeted manner, for example after a complicated fracture or after severe tissue loss following surgery. This has been demonstrated by researchers at Martin Luther ...
Feb 9, 2023
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Fraunhofer researchers have succeeded in using the bioresorbable silica gel Renacer to produce an electrospun membrane that is neither cytotoxic to cells nor genotoxic. This model mimics fibrous structures found in connective ...
Feb 3, 2023
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Contact lenses are a popular vision correction option used by about 10% of the population in Korea—roughly 5 to 6 million people—according to statistics from the Korean Ophthalmological Society. A common contact lens ...
Jan 30, 2023
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Researchers at University of California San Diego School of Medicine have discovered a molecular pathway critical to the initiation of pancreatic tumors. The mechanism could also contribute to the disease's high resistance ...
Jan 16, 2023
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A collaborative team, which includes scientists from the Terasaki Institute for Biomedical Innovation (TIBI), University of Illinois Chicago (UIC), and Pohang University of Science and Technology (POSTECH) has elucidated ...
Dec 21, 2022
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In biology, the extracellular matrix (ECM) is the extracellular part of animal tissue that usually provides structural support to the animal cells in addition to performing various other important functions. The extracellular matrix is the defining feature of connective tissue in animals.
Extracellular matrix includes the interstitial matrix and the basement membrane. Interstitial matrix is present between various animal cells (i.e., in the intercellular spaces). Gels of polysaccharides and fibrous proteins fill the interstitial space and act as a compression buffer against the stress placed on the ECM. Basement membranes are sheet-like depositions of ECM on which various epithelial cells rest.
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