Genetics

Gene loss can lead to accumulation of waste products in cells

MIT biologists have discovered a function of a gene that is believed to account for up to 40 percent of all familial cases of amyotrophic lateral sclerosis (ALS). Studies of ALS patients have shown that an abnormally expanded ...

Alzheimer's disease & dementia

What is the difference between Alzheimer's and dementia?

Alzheimer's and related forms of dementia are commonplace with the Centers for Disease Control and Prevention reporting that 5.8 million people in the United States live with these diseases. This number is expected to rise ...

Alzheimer's disease & dementia

Broken brain cells repaired in dementia mouse model

Dysfunctional neurons in the hippocampus of adult female mice modeling dementia can be repaired and reconnected to distant parts of the brain, reports a new study published in JNeurosci. The similarity between the mouse model ...

Genetics

'RNA sponge' mechanism may cause ALS/FTD neurodegeneration

The most common genetic cause of both ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) was recently identified as an alteration in the gene C9orf72. But how the mutation causes neurodegenerative disease ...

Neuroscience

What is frontotemporal degeneration?

Frontotemporal degeneration (FTD) is a group of neurologic disorders associated with changes in personality, behavior, language or movement. Some FTD forms are inherited, and some are not. Typically, people develop FTD symptoms ...

Neuroscience

Uncovering a key relationship in ALS

A University of Toronto research team has discovered new details about a key gene involved in ALS, perhaps humanity's most puzzling, intractable disease.

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