Ewing's Sarcoma is an aggressive pediatric cancer, most commonly caused by the improper fusion of the gene EWS with the gene FLI1. Though the cause has long been known, therapeutic targeting of this fusion has to date proven ...
Jan 22, 2014
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When sections from two separate genes merge due to various factors, such as translocation or splicing, the hybrid that is formed is called a gene fusion. In recent years, it has been discovered that these fusion events play ...
Nov 20, 2019
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There are many ways a gene can be altered and there are many genes that, when altered, can cause cancer. Testing individually for each possible alteration in every cancer-related gene is not feasible as it would require hundreds ...
Aug 30, 2017
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A fusion gene is a single composite gene resulting from the combination of two formerly independent genes. Researchers from Kumamoto University, Japan have determined that a particular fusion gene is often found in cutaneous ...
Dec 15, 2017
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Establishing the way in which a genetic alteration called a TMPRSS2-ERG gene fusion forms in a prostate cancer, rather than the presence of the gene fusion itself, could help identify patients with prostate cancer with a ...
Nov 10, 2017
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Identification of specific gene fusions is critical for the successful targeted treatment of pediatric cancer patients. Researchers at Children's Hospital Los Angeles have developed a novel assay that automatically integrates ...
Feb 13, 2024
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New research suggests a novel strategy to target a genetic anomaly that occurs in half of all prostate cancers.
Mar 23, 2017
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Geneticists led by University of Utah Nobel Prize Laureate Mario R. Capecchi, Ph.D., have engineered mice that develop clear cell sarcoma (CCS), a significant step in better understanding how this rare and deadly soft tissue ...
Feb 11, 2013
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A new research perspective titled "HER3- A key survival pathway and an emerging therapeutic target in metastatic colorectal cancer and pancreatic ductal adenocarcinoma" has been published in Oncotarget.
May 24, 2023
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Researchers have identified a potential new pathway in prostate cancer cells by which cancer-driving gene products can be generated, according to a study published in Cancer Discovery, a journal of the American Association ...
Jun 19, 2012
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