Genetics

Unexpected findings uncover new understanding of gene expression

Northwestern Medicine scientists have discovered that the catalytic activity of the fly enzyme Trr and mammalian MLL3/MLL4—members of the COMPASS family of proteins central to gene expression—is not required for proper ...

Neuroscience

When the brain's wiring breaks

Among all the bad things that can happen to the brain when it is severely jolted – in a car accident, for example – one of the most common and worrisome is axon damage. Axons are the long stalks that grow out of the bodies ...

Genetics

Gene variant activity is surprisingly variable between tissues

Every gene in almost every cell of the body is present in two variants called alleles—one from the mother, the other one from the father. In most cases, both alleles are active and transcribed by the cells into RNA. However, ...

Arthritis & Rheumatism

Gene expression may predict response to methotrexate in RA

(HealthDay)—For patients with rheumatoid arthritis (RA), increased baseline gene expression of p21, caspase 3, and runt-related transcription factor (RUNX)2 in the peripheral blood may be associated with improved clinical ...

Health

Vitamin D may improve sunburn, according to new clinical trial

High doses of vitamin D taken one hour after sunburn significantly reduce skin redness, swelling, and inflammation, according to double-blinded, placebo-controlled clinical trial out of Case Western Reserve University School ...

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