By comparing two strains of mice—one that becomes obese and diabetic on a high-fat diet and another resistant to a high-fat regimen—researchers from the Perelman School of Medicine at the University of Pennsylvania identified ...
Mar 8, 2017
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Scientists from the Engelhardt Institute of Molecular Biology and MIPT have studied the effects of Siberian fir terpenoids on senescent and human cancer cell lines at the genetic level. Research into terpenoids, including ...
Feb 28, 2017
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Obesity often leads to insulin resistance, a hallmark of type 2 diabetes. The anti-diabetic drug rosiglitazone counters insulin resistance in diabetic patients by targeting PPARγ, a nuclear receptor that senses hormones ...
Feb 27, 2017
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A handful of FDA-approved drugs exist for treating individuals with alcohol use disorder but they have been largely ineffective at reducing the high rates of relapse. As such, there remains a critical need to identify and ...
Jan 30, 2017
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Japanese researchers have found that genes respond differently to the amount and rate of secretions of insulin, a hormone whose malfunction can lead to obesity and diabetes. Some genes express themselves quickly when stimulated ...
Nov 22, 2016
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(HealthDay)—Interleukin (IL)-32 has inflammatory and remodeling properties in human obesity, according to a study published online Sept. 14 in Diabetes.
Sep 20, 2016
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Older people with higher amounts of a key protein in their brains also had slower decline in their memory and thinking abilities than people with lower amounts of protein from the gene called brain-derived neurotrophic factor, ...
Jan 27, 2016
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Researchers at the Howard Hughes Medical Institute's Janelia Research Campus have uncovered unexpected diversity within a single, canonical cell type of the mammalian brain. Their analysis of cells called CA1 pyramidal neurons ...
Jan 18, 2016
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A team of Swiss geneticists from the University of Geneva (UNIGE), the École Polytechnique Fédérale de Lausanne (EPFL), and the University of Lausanne (UNIL) discovered that genetic variation has the potential to affect ...
Aug 20, 2015
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A new computational method developed by scientists from the University of Chicago improves the detection of genes that are likely to be causal for complex diseases and biological traits. The method, PrediXcan, estimates gene ...
Aug 10, 2015
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