Polycomb group (PcG) proteins comprise the polycomb complexes PRC1 and PRC2 that regulate gene expression levels through histone modification. Although PRC1 and PRC2 have important roles in cancer stem cells, their functions ...
Jun 14, 2017
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Batman and Robin. Sherlock Holmes and Dr. Watson. Fiction is full of dynamic duos that work together to accomplish amazing feats. When one partner is out of commission, the other steps in to make sure the job gets done. But ...
May 31, 2017
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In the search for a defining feature of the Escherichia coli that cause urinary tract infections, comparative transcriptomics and infection models show that infection depends on both the host environment and gene expression ...
Mar 23, 2017
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Studies of autoimmune and inflammatory diseases have identified hundreds of genetic regions thought to be associated with these conditions. At the same time, studies of expression quantitative trait loci (eQTLs) have revealed ...
Mar 15, 2017
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By comparing two strains of mice—one that becomes obese and diabetic on a high-fat diet and another resistant to a high-fat regimen—researchers from the Perelman School of Medicine at the University of Pennsylvania identified ...
Mar 8, 2017
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Scientists from the Engelhardt Institute of Molecular Biology and MIPT have studied the effects of Siberian fir terpenoids on senescent and human cancer cell lines at the genetic level. Research into terpenoids, including ...
Feb 28, 2017
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Obesity often leads to insulin resistance, a hallmark of type 2 diabetes. The anti-diabetic drug rosiglitazone counters insulin resistance in diabetic patients by targeting PPARγ, a nuclear receptor that senses hormones ...
Feb 27, 2017
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A handful of FDA-approved drugs exist for treating individuals with alcohol use disorder but they have been largely ineffective at reducing the high rates of relapse. As such, there remains a critical need to identify and ...
Jan 30, 2017
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Japanese researchers have found that genes respond differently to the amount and rate of secretions of insulin, a hormone whose malfunction can lead to obesity and diabetes. Some genes express themselves quickly when stimulated ...
Nov 22, 2016
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(HealthDay)—Interleukin (IL)-32 has inflammatory and remodeling properties in human obesity, according to a study published online Sept. 14 in Diabetes.
Sep 20, 2016
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