Medical research

Making 'sense' of the 'cart before the horse' in mammalian cells

A fusion gene is a new gene made by joining parts of two different genes. The current thought is that fusion genes can happen in cells with unstable genome when part of the DNA from one chromosome moves to another chromosome. ...

Oncology & Cancer

Scientists map the genetic evolution of childhood leukaemia

The key genetic events responsible for initiating the early stages of a type of childhood leukaemia have been identified by scientists at The Institute of Cancer Research, London. Insights into the 'founder' genetic mutation ...

Oncology & Cancer

Gene fusion shifts cell activity into high gear, causing some cancer

The fusion of two adjacent genes can cause cancer by kicking mitochondria into overdrive and increasing the amount of fuel available for rampant cell growth, researchers at Columbia University Medical Center (CUMC) have discovered. ...

Oncology & Cancer

Frequent sun exposure may cue gene fusion found in skin cancer

A fusion gene is a single composite gene resulting from the combination of two formerly independent genes. Researchers from Kumamoto University, Japan have determined that a particular fusion gene is often found in cutaneous ...

Oncology & Cancer

New link seen between gene fusion and bladder cancer

(HealthDay)—The fibroblast growth factor receptor 3 (FGFR3) transforming acidic coiled-coil containing protein 3 (TACC3) (FT3) gene fusion recruits endogenous TACC3 away from the mitotic spindle, resulting in errors in ...

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