Scientists from the USC Stem Cell laboratory of Neil Segil have identified a natural barrier to the regeneration of the inner ear's sensory cells, which are lost in hearing and balance disorders. Overcoming this barrier may ...
Jul 30, 2021
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A chemical modification that occurs in some RNA molecules as they carry genetic instructions from DNA to cells' protein-making machinery may offer protection against non-alcoholic fatty liver, a condition that results from ...
Jul 19, 2021
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How do cis-regulatory genome elements regulate gene expression, what are the critical components involved, and can we therapeutically target them? By investigating how corepressors modulate enhancers and silencers during ...
Jan 27, 2021
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Scientists have identified two drugs that are potent against acute myeloid leukemia (AML) when combined, but only weakly effective when used alone. The researchers were able to significantly enhance cancer cell death by jointly ...
Jan 19, 2021
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New research from Sanford Burnham Prebys Medical Discovery Institute (SBP) is among the first to describe how an mRNA modification impacts the life of neural stem cells (NSCs). The study, published in Nature Neuroscience, ...
Jan 24, 2018
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With advances in genomics, scientists are discovering additional components of the DNA alphabet in animals. Do these unusual chemical modifications of DNA have a special meaning, or are they just signs that cellular machines ...
Oct 24, 2017
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We are more than the sum of our genes. Epigenetic mechanisms modulated by environmental cues such as diet, disease or lifestyle take a major role in regulating the DNA by switching genes on and off. It has been long debated ...
Jul 14, 2017
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The complex process regulating gene expression is often compared to following a recipe. Miss a genetic ingredient, or add it in the wrong order, and you could have a disaster on your hands.
Dec 15, 2016
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Scientists from the German Center for Neurodegenerative Diseases have shed new light on the molecular basis of memory. Their study confirms that the formation of memories is accompanied by an altered activity of specific ...
Dec 18, 2015
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Dirk Schübeler and his group at the Friedrich Miescher Institute for Biomedical Research (FMI) identify determinants that set epigenetic marks along the genome. The new study, published in Nature, shows that genetic activity ...
Feb 10, 2015
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