Oncology & Cancer
Gene research could push cancer research forward
New research by scientists at the Australian National University (ANU) will help us better understand rare forms of cancer.
May 4, 2020
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News tagged with genetic alterations
Genetics
Overactive enzyme causes hereditary hypertension
A Turkish family from a village near the Black Sea caught the attention of medical researchers in the early 1970s, when a physician discovered that many members of this large family had both unusually short fingers and astronomically ...
Jun 11, 2020
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Oncology & Cancer
Molecule Nutlin-3a activates a signal inducing cell death and senescence in primary brain tumors
Researchers of Apoptosis and Cancer Group of the Bellvitge Biomedical Research Institute (IDIBELL) have found that a small molecule, Nutlin-3a, an antagonist of MDM2 protein, stimulates the signalling pathway of another protein, ...
Apr 20, 2011
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Genetics
Neuroblastoma patients with ARID1A and ARID1B mutations have more aggressive disease
In a genome sequencing study of 74 neuroblastoma tumors in children, scientists at the Johns Hopkins Kimmel Cancer Center and the Children's Hospital of Philadelphia (CHOP) found that patients with changes in two genes, ARID1A ...
Dec 2, 2012
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Oncology & Cancer
Stop signal for leukemia stem cells
There are numerous specialized growth factors that are responsible for cells of different tissues of our body to divide and differentiate when needed. These hormone-like factors bind to matching receptors on the surface of ...
Aug 23, 2011
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Genetics
Lifestyle influences metabolism via DNA methylation
An unhealthy lifestyle leaves traces in the DNA. These may have specific effects on metabolism, causing organ damage or disease. Scientists of Helmholtz Zentrum München have now identified 28 DNA alterations associated with ...
Sep 20, 2013
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Oncology & Cancer
Defects in the packaging of DNA in malignant brain tumors
Glioblastomas grow extremely aggressively into healthy brain tissue and, moreover, are highly resistant to radiation therapy and chemotherapy. Therefore, they are regarded as the most malignant type of brain tumor. Currently ...
Jan 30, 2012
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Oncology & Cancer
Genetic makeup may make radiation riskier for pediatric cancer patients
Genetic vulnerabilities associated with childhood cancers may make children undergoing radiation therapy more susceptible than adults to secondary cancers, according to novel insights from researchers at UC San Francisco.
Sep 4, 2015
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Medical research
Genetically modified mice pave the way for customized medicine in a rare disease
An international research team led by Dr. Ana Guadaño at the Alberto Sols Biomedical Research Institute (IIBM, a combined CSIC-UAM center) and involving the Complutense University of Madrid (UCM), used CRISPR gene editing ...
Dec 12, 2022
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Genetics
Study finds new genetic defects in high-risk childhood leukemia subtypes with chromosomal loss
Research led by St. Jude Children's Research Hospital scientists has identified a possible lead in treatment of two childhood leukemia subtypes known for their dramatic loss of chromosomes and poor treatment outcomes.
Jan 20, 2013
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