Esophageal adenocarcinoma (EAC) is a highly lethal cancer, with a five-year survival rate of less than 20%. Although a precursor lesion to EAC, called Barrett's esophagus (BE), is present in roughly 7% of middle-aged adults, ...
Jul 27, 2023
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Researchers have developed a new integrated genetic/epigenetic DNA-sequencing protocol known as MultiMMR that can identify the presence and cause of mismatch repair (MMR) deficiency in a single test from a small sample of ...
Jan 21, 2021
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A large international trial involving UCL and University College London Hospitals NHS Foundation Trust (UCLH) has found that pembrolizumab, a form of immunotherapy, more than doubled the 'progression free survival' time of ...
May 29, 2020
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Our DNA is under constant attack. The delicate molecule that contains our genetic information is extremely vulnerable to everything from environmental agents, such as radiation, to the chemicals in the air we breathe and ...
Jan 10, 2019
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Scientists have put precise timings on the history of a patient's cancer for the first time, effectively 'carbon dating' the different stages in the disease's progression.
May 10, 2017
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Scientists at the Francis Crick Institute have described the molecular structure of a key tumour suppressor protein and provided insights into its role in cells.
Jan 11, 2017
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E-cigarette vapour does not induce DNA mutations commonly observed with tobacco smoke exposures in lab-based tests.
Nov 4, 2016
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Cancerous tumors may be poised at the edge of their own destruction, an insight that could help researchers find new, more effective treatments, suggest SFI External Professor Ricard Solé and colleagues in an April 9 paper ...
Apr 24, 2014
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(Medical Xpress)—Researchers at The Jackson Laboratory have identified a molecule that prevents repair of some cancer cells, providing a potential new "genetic chemotherapy" approach to cancer treatment that could significantly ...
Apr 17, 2013
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Lynch Syndrome is a heritable genetic mutation that causes colorectal, endometrial and other cancers. A cooperative study that included the University of Colorado Cancer Center, published in this month's issue of the Journal ...
Feb 26, 2013
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