Cardiology

Defective cilia linked to heart valve birth defects

Bicuspid aortic valve (BAV) is the most common heart valve birth defect and one of the most common birth defects of any type, affecting around 70 million people worldwide. A healthy aortic valve has three leaflets; in BAV ...

Oncology & Cancer

Cancer susceptibility genes

Genome-wide association studies (GWASs) have identified hundreds of genetic "risk" variants for human cancers. The vast majority likely contribute to cancer development by regulating the expression of other genes, but these ...

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