Chromosomal errors are a hallmark of cancer cells. Defects in the genome derived from the incorrect separation of chromosomes (and the DNA packed within) in each division of cells drive tumor growth and resistance to therapy.
Apr 24, 2023
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A single cell contains 2-3 meters of DNA, meaning that the only way to store it is to package it into tight coils. The solution is chromatin: a complex of DNA wrapped around proteins called histones. In the 3D space, this ...
Mar 15, 2023
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A new clinical and preclinical study from UCLA Jonsson Comprehensive Cancer Center identifies the DNA roots of resistance to targeted cancer therapy, providing a possible strategy to address a vexing issue in cancer therapeutics. ...
Jan 26, 2023
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Error-prone DNA replication and repair may lead to mutations and cancer in individuals who inherit a mutant copy of the BRCA1 gene, according to a new study by Weill Cornell Medicine investigators. The discovery has potential ...
Nov 15, 2022
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A team of researchers from Weill Cornell Medicine, the British Columbia Cancer Research Centre and Memorial Sloan Kettering Cancer Center, working with a group from the IMAXT Consortium, has used single-cell sequencing to ...
Mutations occur in various tissues and organs of an individual. Somatic mutations occur in cells that will not give rise to offspring and are therefore not passed on to subsequent generations. Caused by a large number of ...
Jul 5, 2022
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The urgency to remember a dangerous experience requires the brain to make a series of potentially dangerous moves: Neurons and other brain cells snap open their DNA in numerous locations—more than previously realized, according ...
Jul 6, 2021
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A new University of California, Irvine-led study reveals a protein responsible for genetic changes resulting in a variety of cancers, may also be the key to more effective, targeted cancer therapy.
Jun 12, 2020
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Two genes that appear to help stem cells in the intestine burn dietary fat may play a role in colon cancer, according to a Rutgers study.
Nov 25, 2019
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The ARID1A tumor suppressor protein is required to maintain telomere cohesion and correct chromosome segregation after DNA replication. This finding, reported by Wistar researchers in Nature Communications, indicates that ...
Sep 6, 2019
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