Johns Hopkins and other cancer researchers report that a very short course of a chemotherapy drug, called cyclophosphamide, not only can prevent a life-threatening immune response in some bone marrow transplant recipients, ...
Oct 8, 2014
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(HealthDay)—For patients undergoing myeloablative allogeneic hematopoietic stem cell transplantation, sitagliptin combined with tacrolimus and sirolimus results in a low incidence of grade II to IV acute graft-versus-host ...
Jan 7, 2021
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Bone marrow transplants have saved the lives of thousands of blood cancer patients, but graft-versus-host disease, or GVHD, remains a debilitating and even life-threatening complication. A new study from Fred Hutchinson Cancer ...
Aug 7, 2023
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An HIV drug that redirects immune cell traffic significantly reduces the incidence of a dangerous complication that often follows bone marrow transplants for blood cancer patients, according to research from the Perelman ...
Jul 11, 2012
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A new analysis shows that a donor stem cell transplant following treatment with an immune checkpoint inhibitor is generally safe and produces good outcomes for patients with Hodgkin lymphoma, easing concerns that these patients ...
Dec 9, 2019
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New research challenges the prevailing hypothesis for how donor stem cell grafts cause graft-versus-host disease, or GVHD, and offers an alternative model that could guide development of novel therapies.
Jan 30, 2023
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Results of a Johns Hopkins study may explain why a chemotherapy drug called cyclophosphamide prevents graft-versus-host (GVHD) disease in people who receive bone marrow transplants. The experiments point to an immune system ...
Nov 13, 2013
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An experimental antibody treatment largely prevented a bone marrow transplant complication called graft versus host disease (GVHD) in the intestines, without causing broad immune suppression, in a preclinical study led by ...
Jun 28, 2023
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For someone with a blood cancer, receiving stem cells from a donor offers the possibility of a cure. But patients undergoing this procedure, called allogeneic hematopoietic cell transplantation, also face the possibility ...
Aug 1, 2023
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A drug used for rheumatoid arthritis has moved a step closer to FDA approval for a desperately needed new use. The drug, abatacept, has gained FDA Breakthrough Therapy Designation for preventing acute, severe graft-versus-host ...
Dec 4, 2019
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