Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer and is projected to become the second-leading cause of cancer-related death by 2030. Although progress has been made in improving outcomes, ...
May 28, 2024
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The death of sensory hair cells in the ear results in irreversible hearing loss. Several classes of drugs, including aminoglycoside antibiotics and chemotherapy drugs are known to kill hair cells; however, in many cases the ...
Oct 15, 2013
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At Genetics Society of America's Drosophila Research Conference, scientists will report on results of using fly models to investigate passive immunotherapy to block amyloid-β42 peptides of amyloid plaques that damage the ...
Mar 26, 2014
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Opioid drugs such as morphine and fentanyl are like the two-faced Roman god Janus: The kindly face delivers pain relief to millions of sufferers, while the grim face drives an opioid abuse and overdose crisis that claimed ...
May 31, 2023
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Although cancers are commonly classified and named by site of origin, and effective drugs are FDA-approved accordingly, a research team at Dartmouth's Norris Cotton Cancer Center has found that multiple organ sites share ...
Oct 24, 2019
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Protein production or translation is tightly coupled to a highly conserved stress response that cancer cells rely on for survival and proliferation, according to Whitehead Institute researchers. In mouse models of cancer, ...
Jul 18, 2013
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New research reveals the presence of abundant levels of a certain protein in the kidneys of patients with fibrillary glomerulonephritis (FGN). In FGN, large amounts of protein become trapped in the millions of filtering units—or ...
Nov 2, 2017
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Researchers have found in mice that supporting cells in the inner ear, once thought to serve only a structural role, can actively help repair damaged sensory hair cells, the functional cells that turn vibrations into the ...
Jul 25, 2013
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Chronic gastrointestinal (GI) disorders are becoming increasingly common throughout the world, but many of them still lack effective treatment. Researchers have now turned to natural compounds, such as those present in traditional ...
Nov 27, 2023
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Malaria caused by the parasite Plasmodium falciparum remains a major public health problem worldwide. As a continuation of previous research targeting Hsp90, a universal molecular chaperone performing vital functions both ...
Jul 7, 2016
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