An international research team reports in Nature Medicine a novel molecular pathway that causes an aggressive form of medulloblastoma, and suggests repurposing an anti-depressant medication to target the new pathway may help ...
Aug 24, 2014
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Two Johns Hopkins neuroscientists have discovered the "molecular brakes" that time the generation of important cells in the inner ear cochleas of mice. These "hair cells" translate sound waves into electrical signals that ...
Sep 16, 2014
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Researchers from Charité - Universitätsmedizin Berlin have discovered that the survival of cancer stem cells is dependent on the Hedgehog signaling pathway. Targeting this pathway had previously shown no effect on the growth ...
Jan 22, 2018
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Erxi Wu, assistant professor of pharmaceutical sciences, co-wrote the review article, “The paracrine Sonic Hedgehog signaling derived from tumor epithelial cells: A key regulator in the pancreatic tumor microenvironment,” ...
Feb 17, 2012
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Scientists have identified the key molecular pathway leading to depression, revealing potential new targets for drug discovery, according to research led by King's College London's Institute of Psychiatry. The study, published ...
Dec 6, 2012
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Hailed as a major step forward in the effort to develop targeted cancer therapies, a recently approved drug for the most common type of skin cancer has been a mixed blessing for patients. Although the initial response is ...
Feb 27, 2013
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For the first time, a highly transmissible strain of the antibiotic-resistant superbug MRSA currently plaguing hospitals in Northern Europe has been isolated from hedgehogs in Helsinki. The study by Venla Johansson and colleagues ...
Apr 22, 2022
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Genetic mutations affecting a single gene play an outsized role in Parkinson's disease. The mutations are generally responsible for the mass die-off of a set of dopamine-secreting, or dopaminergic, nerve cells in the brain ...
Nov 15, 2018
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Identification of a non-traditional pathway for spiriting a cancer-promoting protein into the cell nucleus points to a possible combination therapy for esophageal cancer and indicates a mechanism of resistance for new drugs ...
Mar 19, 2012
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Scientists at Dana-Farber/Boston Children's Cancer and Blood Disorders Center have identified a protein critical to both the normal development of the brain and, in many cases, the development of medulloblastoma, a fast-growing ...
Mar 26, 2015
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