Genetics

Rare disease's mutation could explain more common conditions

TREX1 is a gene that is supposed to direct the maintenance of the entire body's DNA, but new research shows that when people are born with mutated TREX1, it causes catastrophic damage to the DNA over time, resulting in a ...

Oncology & Cancer

Characterization of mutational 'coldspots' in the cancer genome

Mutations are the changes in the DNA that gradually occur in human cells as they replicate, and the organism grows and ages. Some of these changes, particularly when they occur in genes, can be instrumental during the development ...

Genetics

New atlas of mRNA variants captures inner workings of the brain

Investigators at Weill Cornell Medicine have assembled the most comprehensive atlas to date of messenger RNA (mRNA) variants in the mouse and human brain. The atlas is an important new resource in understanding brain development, ...

Medical research

Understanding the wiring of the human genome

Around 98.5% of human DNA is non-coding, meaning it doesn't get copied to make proteins. A new study has connected many of these non-coding regions to the genes they affect and laid out guidelines for how researchers can ...

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