Researchers have demonstrated that a refined gene therapy approach safely restores the immune systems of some children with severe combined immunodeficiency (SCID). The rare condition blocks the normal development of a newborn's ...
Sep 11, 2012
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Oncogenes are generally thought to be genes that, when mutated, change healthy cells into cancerous tumor cells. Scientists at the Keck School of Medicine of the University of Southern California (USC) have proven that those ...
Jul 18, 2011
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Breast cancer is the second-most common cancer diagnosis for U.S. women, and the second-leading cause of female cancer deaths. In recent years, breast cancer treatments have improved significantly, thanks to targeted gene ...
Apr 24, 2024
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Recent clinical trials utilizing high doses of adeno-associated virus (AAV) vectors have highlighted a new challenge to AAV gene transfer—activation of the complement system. A new article in Human Gene Therapy describes ...
Feb 22, 2024
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A new study, published online ahead of print in Journal for ImmunoTherapy of Cancer on December 6, has identified a novel biomarker for ICIs in human cancers.
Dec 13, 2023
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Hungarian-born scientist Katalin Kariko's obsession with researching a substance called mRNA to fight disease once cost her a faculty position at a prestigious US university, which dismissed the idea as a dead end.
Oct 2, 2023
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A new study characterizes a bioengineered adeno-associated virus (AAV)3B capsid variant that demonstrates improved transduction to human liver cells. Another advantage of the AAV3B-V04 capsid was its significantly reduced ...
Apr 25, 2023
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The use of a monoclonal antibody that reduced circulating IgG levels, led to a decrease in preexisting neutralizing antibodies (NAbs) to adeno-associated virus (AAV). The study, which showed that this strategy enabled gene ...
Mar 22, 2023
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New advanced therapies can alleviate or cure chronic diseases. But medical progress raises the question of how rights should be protected and balanced, according to Jessica Almqvist, professor in international law and human ...
Dec 22, 2022
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Patients with cancer who were living with human immunodeficiency virus (HIV) infection had increased epigenetic age—a type of biological age defined by DNA methylation patterns—compared with patients with cancer without ...
Nov 18, 2022
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