Medical research

Mouth rinse for HPV DNA may be biomarker in head, neck cancer

(HealthDay)—Human papillomavirus (HPV) DNA detected from a mouth rinse may be an effective marker for prognosis during treatment of HPV-positive head and neck cancer, according to a study recently published in JAMA Oncology.

Oncology & Cancer

CDC: Recent decline seen in high-grade cervical lesions

(HealthDay)—The number of cervical precancers (CIN2+ cases) in the United States declined from 2008 to 2016, likely in part because of prevention with the human papillomavirus (HPV) vaccine, according to research published ...

Oncology & Cancer

Why the HPV vaccine is more important than ever

(HealthDay)—HPV, the human papillomavirus, is the most common sexually transmitted infection in the United States, with 14 million new cases each year.

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Human papillomavirus

Alphapapillomavirus Betapapillomavirus Gammapapillomavirus Mupapillomavirus Nupapillomavirus

A human papillomavirus (HPV) is a papillomavirus that infects the epidermis and mucous membranes of humans. HPV can lead to cancers of the cervix, vulva, vagina, and anus in women. In men, it can lead to cancers of the anus and penis.

Approximately 130 HPV types have been identified. Some HPV types can cause warts (verrucae), but those types don't cause cancer. Other types can cause cancer, but those types don't cause warts. Other types have no symptoms and are harmless. Most people who become infected with HPV do not know they have it.

About 30-40 HPV types are typically transmitted through sexual contact and infect the anogenital region. Some sexually transmitted HPV types may cause genital warts. Persistent infection with "high-risk" HPV types—different from the ones that cause warts—may progress to precancerous lesions and invasive cancer. HPV infection is a cause of nearly all cases of cervical cancer. However most infections with these types do not cause disease.

Most HPV infections in young females are temporary and have little long-term significance. 70% of infections are gone in 1 year and 90% in 2 years.

A cervical Papanicolaou (Pap) test is used to detect abnormal cells which may develop into cancer. A cervical examination also detects warts and other abnormal growths which become visible as white patches of skin after they are washed with acetic acid. Abnormal and cancerous areas can be removed with a simple procedure, typically with a cauterizing loop.

Pap smears have reduced the incidence and fatalities of cervical cancer in the developed world, but even so there were 11,000 cases and 3,900 deaths in the U.S. in 2008. Cervical cancer has substantial mortality in resource-poor areas; worldwide, there are 490,000 cases and 270,000 deaths.

HPV vaccines, Gardasil and Cervarix, which prevent infection with the HPV types (16 and 18) that cause 70% of cervical cancer, may lead to further decreases.

This text uses material from Wikipedia, licensed under CC BY-SA