Oncology & Cancer

Modifying the major model of a modern major mouse model

If a new anti-cancer drug shows promise in a Petri dish, often the next step is to test the drug's effect in mice. This system tends to work well with drugs that directly target cancer, but breaks down with immunotherapies. ...

Oncology & Cancer

New model paves way for immune therapies against colorectal cancer

About 95 percent of colorectal cancers are considered "microsatellite stable" and very few of these cancers respond to immunotherapy, meaning that the vast majority of metastatic colorectal cancer patients are unable to benefit ...

Oncology & Cancer

Long-sought genetic model of common infant leukemia described

After nearly two decades of unsuccessful attempts, researchers from the University of Chicago Medicine and the Cincinnati Children's Hospital Medical Center have created the first mouse model for the most common form of infant ...

Diseases, Conditions, Syndromes

Trophoblasts unlikely placental entry point for Zika

Two unrelated studies on the Zika virus—one ruling out a theory for how Zika may be passing through the human placenta and another on using mouse models to trace Zika pathogenesis—appear April 5 in Cell Host & Microbe.

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