In preclinical studies, tumors that consitutively expressed the protein indoleamine 2,3-dioxygenase (IDO1) responded to the cyclooxygenase-2 (COX-2) inhibitor celecoxib (Celebrex) and had improved infiltration of certain ...
Jul 21, 2017
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Type I diabetes (T1D) is an autoimmune condition that develops after the immune system attacks and destroys pancreatic β cells, leading to impaired insulin production. Currently, no therapies can successfully reverse the ...
Apr 4, 2017
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Prostate cancer, notoriously resistant to immunotherapy due to its immunologically cool nature, triggers two pathways to chill an immune attack after one immunotherapy drug fires up the immune system, researchers at The University ...
Mar 27, 2017
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With the aid of thousands of skin biopsies and over a hundred kilograms of skin, researchers at Karolinska Institutet have observed how two subgroups of immune cell behave in healthy skin. This functional dichotomy is preserved ...
Feb 20, 2017
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Obesity and a diet high in fat could lead to a harmful activation of the immune system, increasing a person's risk of heart disease, according to a study led by Queen Mary University of London (QMUL).
Feb 13, 2017
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A Yale-led research team identified how insulin-producing cells that are typically destroyed in type 1 diabetes can change in order to survive immune attack. The finding may lead to strategies for recovering these cells in ...
Feb 9, 2017
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Of the more than 700,000 Americans who suffer a heart attack each year, about a quarter go on to develop heart failure. Scientists don't fully understand how one condition leads to the other, but researchers in the Perelman ...
Feb 6, 2017
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After a heart attack, or myocardial infarction, a patient's long-term prognosis depends on the ability of the heart tissue to heal and remodel. Immune system activation and inflammatory responses that occur in the aftermath ...
Feb 6, 2017
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In several types of cancer, elevated expression of the chemokine receptor CCR4 in tumors is associated with poor patient outcomes. Communication through CCR4 may be one mechanism that cancer cells use to create a pro-tumor ...
Jan 30, 2017
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(Medical Xpress)—A team of researchers at the National Institutes of Health has found another part of the process that allows mosquitoes to keep from getting malaria even as they carry the parasite responsible for the disease ...
