Silencing cancer cell communication may reduce the growth of tumors

January 30, 2017

In several types of cancer, elevated expression of the chemokine receptor CCR4 in tumors is associated with poor patient outcomes. Communication through CCR4 may be one mechanism that cancer cells use to create a pro-tumor environment that protects tumors from immune system attacks. Antibodies that block CCR4 are currently in clinical trials for treating blood and lymphatic cancers, but these approaches may also effectively target cancers that produce solid tumors.

In this issue of the JCI, a study led by Frances Balkwill at Barts Cancer Institute evaluated whether blocking CCR4 in a mouse model of cancer could counteract the signaling that creates a pro-tumor environment.

In mice with , antibody-mediated inhibition of CCR4 changed the composition of immune cell populations that were present in the tumor microenvironment. The changes were associated with reduced tumor proliferation, suggesting that inhibition of CCR4 had anti-tumor effects.

These results highlight anti-CCR4 antibodies as a potential therapeutic for multiple cancers that are linked to abnormal CCR4 expression, including ovarian cancer, breast cancer, and glioblastoma.

Explore further: Researchers identify new target for cancer immunotherapy

More information: Chiara Berlato et al, A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer, Journal of Clinical Investigation (2017). DOI: 10.1172/JCI82976

Related Stories

Researchers identify new target for cancer immunotherapy

January 17, 2017
Massachusetts General Hospital investigators have found new evidence that the tumor necrosis factor receptor type II (TNFR2) may be a major target for immuno-oncology treatments, which induce a patient's immune system to ...

Investigational KW-0761 efficiently depletes immune system-suppressing Treg cells

October 1, 2015
Main Finding(s): In a phase Ia clinical trial, immune cells called Tregs, which can inhibit anticancer immune responses, were efficiently eliminated from the blood of patients with lung or esophageal cancer by treatment with ...

Estrogen signaling impacted immune response in cancer

October 17, 2016
While the role of estrogen signaling in tumor development is well understood in breast and ovarian cancer, its role in anti-tumor immunity has not been extensively studied. However, new research from The Wistar Institute ...

T cell channel could be targeted to treat head and neck cancers

November 17, 2016
Researchers at the University of Cincinnati (UC) have discovered that an ion channel, active within T cells (white blood cells), could be targeted to reduce the growth of head and neck cancers.

Genome of Sezary syndrome points to potential treatment targets

November 10, 2015
A genomic analysis of 37 patients with Sézary syndrome, a rare form of T-cell lymphoma that affects the skin and causes large numbers of atypical T-lymphocytes (an immune system disease) to circulate, reveals mutations in ...

Recommended for you

Alternative splicing, an important mechanism for cancer

September 22, 2017
Cancer, which is one of the leading causes of death worldwide, arises from the disruption of essential mechanisms of the normal cell life cycle, such as replication control, DNA repair and cell death. Thanks to the advances ...

'Labyrinth' chip could help monitor aggressive cancer stem cells

September 21, 2017
Inspired by the Labyrinth of Greek mythology, a new chip etched with fluid channels sends blood samples through a hydrodynamic maze to separate out rare circulating cancer cells into a relatively clean stream for analysis. ...

Drug combination may improve impact of immunotherapy in head and neck cancer

September 21, 2017
Checkpoint inhibitor-based immunotherapy has been shown to be very effective in recurrent and metastatic head and neck cancer but only in a minority of patients. University of California San Diego School of Medicine researchers ...

Whole food diet may help prevent colon cancer, other chronic conditions

September 21, 2017
A diet that includes plenty of colorful vegetables and fruits may contain compounds that can stop colon cancer and inflammatory bowel diseases in pigs, according to an international team of researchers. Understanding how ...

New kinase detection method helps identify targets for developing cancer drugs

September 21, 2017
Purdue University researchers have developed a high-throughput method for matching kinases to the proteins they phosphorylate, speeding the ability to identify multiple potential cancer drug targets.

Poliovirus therapy induces immune responses against cancer

September 20, 2017
An investigational therapy using modified poliovirus to attack cancer tumors appears to unleash the body's own capacity to fight malignancies by activating an inflammation process that counter's the ability of cancer cells ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.