Immunotherapy drugs known as checkpoint inhibitors have revolutionized cancer treatment: many patients with malignancies that until recently would have been considered untreatable are experiencing long-term remissions. But ...
Apr 4, 2019
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The advent of immune checkpoint inhibitors—which "release the brakes" of the body's immune system to launch an efficient tumor attack—are a major breakthrough in cancer immunotherapy. However, these treatments don't work ...
Apr 2, 2019
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For the first time, transplanting gut bacteria from healthy donors was used to successfully treat patients suffering from severe colitis caused by treatment with immune checkpoint inhibitors (ICIs). The study from The University ...
Nov 12, 2018
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A unique bacterial strain isolated from a patient with pelvic pain may represent a promising path to treating prostate cancer with immunotherapy, according to a Northwestern Medicine study published in Nature Communications.
Jun 7, 2018
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Johns Hopkins Kimmel Cancer Center researchers demonstrated that mice with ovarian cancer that received drugs to reactivate dormant genes along with other drugs that activate the immune system had a greater reduction of tumor ...
Dec 5, 2017
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It's what's missing in the tumor genome, not what's mutated, that thwarts treatment of metastatic melanoma with immune checkpoint blockade drugs, researchers at The University of Texas MD Anderson Cancer Center report in ...
Mar 1, 2017
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After surgery to remove a cancerous tumor—even if the surgery is considered "successful"—it's nearly impossible to ensure that all microtumors have been removed from the surgical site. Cancer recurrence is always a major ...
Jan 23, 2017
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A new paper published in the journal Nature Communications explores programmed cell death (PD-1) in melanoma cells and the immune system's response.
Aug 28, 2024
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Immunotherapy has revolutionized cancer treatment, with immune checkpoint inhibitors (ICIs) playing a pivotal role. However, current ICIs, primarily monoclonal antibodies, face significant challenges like poor tissue penetration, ...
Aug 22, 2024
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For patients with hepatocellular carcinoma (HCC), immune checkpoint inhibitor (ICI) use prior to liver transplant (LT) does not worsen outcomes, according to research published online July 10 in the Journal of Hepatology.
Aug 19, 2024
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