Immunology

Study unveils T cell signaling process central to immune response

The immune system cells known as T cells play a central role in the body's ability to fight infections and cancer. For decades, however, details of the molecular signaling process that leads to T cell activation have remained ...

Cardiology

Inhibitory signal pathways identified

LMU researchers led by Christian Weber show that the chemokine receptor CXCR4 protects the integrity of arterial walls, and define a new mechanism that restricts the deleterious accumulation of cholesterol in atherosclerotic ...

Oncology & Cancer

Savior of T-cells may be enemy of liver immune cells

Researchers at Houston Methodist demonstrated that a surface protein called OX40, responsible for keeping one type of immune system cell alive, can trigger the death of liver immune cells, in turn starting a chain reaction ...

Medical research

New approach makes cells resistant to HIV

Scientists at The Scripps Research Institute (TSRI) have found a way to tether HIV-fighting antibodies to immune cells, creating a cell population resistant to the virus. Their experiments under lab conditions show that these ...

Oncology & Cancer

Vet study shows how solid tumors resist immunotherapy

Immunotherapies have revolutionized cancer treatment, offering hope to those whose malignancies have stubbornly survived other existing treatments. Yet solid tumor cancers are often resistant to these approaches.

Medications

Opioids produce analgesia via immune cells

Opioids are the most powerful painkillers. Researchers at the Charité - Universitätsmedizin Berlin have now found that the analgesic effects of opioids are not exclusively mediated by opioid receptors in the brain, but ...

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