A study conducted by Jun Sun's research team at the University of Illinois Chicago has revealed a new and critical role of Axin1 in regulating intestinal epithelial development and microbial homeostasis. The research, titled ...
Sep 22, 2023
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Giant cell arteritis (GCA), formerly known as temporal arteritis, was first described by Mayo Clinic doctors and classified as an inflammatory condition of the blood vessels in the early to mid-20th century. The condition ...
Sep 18, 2023
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Kidney stones, hard crystalline formations that occur within the kidney, are a common condition that affects millions of people worldwide. While genetics and various other factors can contribute to kidney stones, dietary ...
Sep 11, 2023
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Everyone loves a sweet treat, even our cells. While we typically think of sugar as a component of our diet that gives us energy, sugars are also very important in guiding the activity of our cells. Sugar molecules can be ...
Sep 5, 2023
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Though oral health issues can affect overall health, the two are considered unrelated and are frequently addressed separately when it comes to treatment. However, existing research shows that patients with inflammatory bowel ...
Plastics—in particular, microplastics—are among the most pervasive pollutants on the planet, finding their way into the air, water systems and food chains around the world. While the prevalence of microplastics in the ...
Aug 28, 2023
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Regulatory T cells—work horses of the body's immune system—may also stabilize mood, according to a study. Forkhead box P3 (Foxp3) is a transcription factor that controls the production of regulatory T cells (Tregs).
Aug 23, 2023
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Researchers have shown that a novel antibody generated to target an 'essential amino acid sequence' of both interleukin-17A and F has greater activity and potentially fewer side effects than existing biological therapies ...
Aug 14, 2023
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A research group led by Clemson University has developed a strategy to improve heart repair using human pluripotent stem cell–derived cardiomyocytes combined with biodegradable and biocompatible electroconductive silicon ...
In Parkinson's disease, growing evidence targets neuroinflammation as essential for brain pathogenesis. But which group of immune cells that reside in the brain direct this inflammatory response?
Aug 9, 2023
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Inflammation (Latin, inflamatio, to set on fire) is the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. It is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue. Inflammation is not a synonym for infection. Even in cases where inflammation is caused by infection, the two are not synonymous: infection is caused by an exogenous pathogen, while inflammation is the response of the organism to the pathogen.
In the absence of inflammation, wounds and infections would never heal and progressive destruction of the tissue would compromise the survival of the organism. However, an inflammation that runs unchecked can also lead to a host of diseases, such as hay fever, atherosclerosis, and rheumatoid arthritis. It is for that reason that inflammation is normally closely regulated by the body.
Inflammation can be classified as either acute or chronic. Acute inflammation is the initial response of the body to harmful stimuli and is achieved by the increased movement of plasma and leukocytes from the blood into the injured tissues. A cascade of biochemical events propagates and matures the inflammatory response, involving the local vascular system, the immune system, and various cells within the injured tissue. Prolonged inflammation, known as chronic inflammation, leads to a progressive shift in the type of cells which are present at the site of inflammation and is characterised by simultaneous destruction and healing of the tissue from the inflammatory process.
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