A team of researchers led by biomedical scientist Declan F. McCole at the University of California, Riverside, has found that the drug tofacitinib, also called Xeljanz and approved by the FDA to treat rheumatoid arthritis ...
Sep 30, 2020
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The intestinal epithelium is the inner layer of the intestinal wall, which separates host tissue from the intestinal microbiota. This layer of cells plays a crucial role in water, electrolyte and nutrient absorption, while ...
Jun 8, 2020
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The small intestine is one of the most important interfaces between the environment and our body. It is responsible for nutrient absorption but also forms a barrier against potentially harmful environmental cues. A research ...
May 1, 2020
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The cotransporter NKCC1 moves sodium, potassium and chloride ions across the cell membrane of many cell types, including intestinal epithelial cells. Two patients with mutations in NKCC1 suffered from severe intestinal dysfunction ...
Apr 22, 2020
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Boston researchers have developed a new way to generate groups of intestinal cells that can be used, among others, to make disease models in the lab to test treatments for diseases affecting the gastrointestinal system. Using ...
Jan 10, 2020
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Intestinal epithelial cells (IECs) are exposed to diverse types of environmental stresses such as bacteria and toxins, but the mechanisms by which epithelial cells sense stress are not well understood. New research by the ...
Sep 25, 2019
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Short bowel syndrome is a debilitating condition with few treatment options, and these treatments have limited efficacy. The ability to grow artificial intestine is a coveted goal with the potential to profoundly improve ...
Sep 18, 2019
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Although the mutually beneficial relationship between human beings and gut microbes is clear, how we—the host—affect the functions of gut microbial communities remains poorly understood.
Aug 19, 2019
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Multiple types of immune cells are interspersed among the epithelial cells lining the intestines and are considered to be a first line of defense against pathogens. The survival and interaction of these intraepithelial lymphocytes ...
Aug 1, 2019
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New research from NC State reveals your body's "backup plan" – in the form of reserve stem cells – for recovering from severe intestinal injury due to lack of blood supply.
Mar 29, 2019
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