Overweight & Obesity

Aldose reductase promotes diet-induced obesity

High-fat diet (HFD) feeding in mice promotes induction of aldose reductase (AR) activity, expression, and senescence of adipocytes in subcutaneous adipose tissue (scAT), according to a new study in Obesity journal.

Neuroscience

In the quest for a TBI therapy, astrocytes may be the bull's-eye

Growing evidence suggests that traumatic brain injury (TBI) is an important risk factor for developing Alzheimer's disease and dementia. But to date, effective therapies aren't available for preventing or treating TBI-induced ...

Immunology

ATP-hydrolyzing ectoenzyme E-NTPD8 attenuates colitis

The intestinal microbial ecosystem includes diverse species of bacteria. These bacteria can produce bioactive metabolites that directly affect the host's immune system. An imbalance of microbial metabolites has been implicated ...

Alzheimer's disease & dementia

Beige fat 'indispensable' in protecting the brain from dementia

Beige is considered a calming paint color, and scientists have new evidence that beige fat has a similar impact on the brain, bringing down the inflammation associated with the more common white fat and providing protection ...

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