The next stage of a Massachusetts General Hospital (MGH) team's investigation into the therapeutic potential of the hypoxia response - the body's reaction to reduced levels of oxygen in the blood - to treat mitochondrial ...
May 8, 2017
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A mouse with dysfunctional mitochondria may hold the key to treating Leigh syndrome in humans.
Jul 18, 2016
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Leuven researchers led by professor Bart De Strooper (VIB-KU Leuven) have identified a new role for PARL, a protein linked to Parkinson's disease. In this week's edition of the Proceedings of the National Academy of Science, ...
Jan 3, 2019
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The transplant anti-rejection drug rapamycin showed unexpected benefits in a mouse model of a fatal defect in the energy powerhouses of cells, the mitochondria. Children with the condition, Leigh syndrome, show progressive ...
Nov 14, 2013
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Salk Institute scientists showed how an FDA-approved drug boosts the health of brain cells by limiting their energy use. Like removing unnecessary lighting from a financially strapped household to save on electricity bills, ...
Apr 26, 2016
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(Medical Xpress) -- Mitochondrial inherited diseases (MIDs) can devastate families, but there is hope in the form of new techniques to prevent them passing from mother to child. Anjana Ahuja speaks to the researchers at the ...
Jun 12, 2012
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In Leigh syndrome, infants are born apparently healthy only to develop movement and breathing disorders that worsen over time, often leading to death by the age of 3. The problem is that the mitochondria responsible for powering ...
Sep 6, 2011
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Over 30 years ago, Marsha and Allen Barnett lost their sons to a puzzling childhood disease that relentlessly attacked their nervous systems and sapped their energy. After five-year-old Chuckie died suddenly in 1981, doctors ...
Nov 15, 2018
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Researchers from the Mitochondrial Medicine Frontier Program at Children's Hospital of Philadelphia (CHOP) have found that developmental delays associated with Leigh syndrome, the most common pediatric mitochondrial disorder, ...
Mar 1, 2022
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Microglia, a type of central nervous system cell, is primarily responsible for neuronal death in Leigh Syndrome and the neurological symptoms related to this mitochondrial disease. This is the conclusion of a research group ...
Jul 8, 2022
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