Just as Goldilocks sought porridge that was "just right," St. Jude Children's Research Hospital scientists reported that targeting "just right" levels of a mutant protein may offer a novel therapeutic approach to some cases ...
Jun 26, 2019
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Immunotherapy with blinatumomab leads to a strongly improved survival rate—from 66% to 93%—for children with an aggressive form of acute lymphoblastic leukemia (ALL). They also had fewer side effects from the treatment. ...
Apr 26, 2023
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Physician-scientists from Children's Hospital of Philadelphia (CHOP) presented updated efficacy and safety data on Kymriah(R) (tisagenlecleucel, formerly CTL019) —the first-ever U.S. Food and Drug Administration (FDA) approved ...
Dec 4, 2018
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All stem cells can multiply, proliferate and differentiate. Because of these qualities, leukemic stem cells are the most malignant of all leukemic cells. Understanding how leukemic stem cells are regulated has become an important ...
Mar 12, 2019
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Since stem cells can continually self-regenerate, making more stem cells, and differentiate into many different specialized cell types, they play an important role in our development and health. But there can also be a dark ...
Jan 26, 2021
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A study at The University of Texas MD Anderson Cancer Center demonstrated how a small molecule drug discovered at the institution may help overcome resistance to treatment with ibrutinib in patients with mantle cell lymphoma.
May 8, 2019
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By using drugs currently used to treat other diseases, scientists hope they will help children with leukemia suffer fewer long-term aftereffects from their treatment.
Aug 31, 2022
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Researchers from Aalto University have found the mechanism of action for cancer-cell-killing peptides. This breakthrough is expected to lead to better medication, in particular better treatments for leukemia, skin cancer, ...
May 27, 2011
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Using the molecularly targeted drug ibrutinib (Imbruvica) together with the investigational anticancer agent ABT-199 may improve outcomes for patients with mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL), ...
Sep 23, 2014
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Some of the relapses in patients with childhood acute lymphoblastic leukemia are due to the fact that the leukemia cells manage to survive treatment by hiding in areas of the Central Nervous System. Research led by Universidad ...
Mar 30, 2022
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