Diseases, Conditions, Syndromes

Brazil recommends chloroquine to treat even mild COVID-19 cases

Brazil's health ministry recommended Wednesday using chloroquine and hydroxychloroquine to treat even mild cases of COVID-19, treatments President Jair Bolsonaro has pushed for despite a lack of conclusive evidence of their ...

Health

Hangover drug shows wider benefits in research

A well-known hangover drug not only helps soothe pounding headaches but also triggers profound changes that protect the liver, USC scientists report in new findings that could help prevent alcohol-related harm.

Medical research

Even damaged livers can handle life-saving medication

When you ingest a drug—whether over-the-counter Tylenol or medication prescribed by a doctor—your liver is your body's first responder. And just like other first responders, sometimes the liver gets hurt. Doctors used ...

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Hepatotoxicity

Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents. Certain medicinal agents when taken in overdoses and sometimes even when introduced within therapeutic ranges may injure the organ. Other chemical agents such as those used in laboratories and industries, natural chemicals (e.g. microcystins) and herbal remedies can also induce hepatotoxicity. Chemicals that cause liver injury are called hepatotoxins.

More than 900 drugs have been implicated in causing liver injury and it is the most common reason for a drug to be withdrawn from the market. Chemicals often cause subclinical injury to liver which manifests only as abnormal liver enzyme tests. Drug induced liver injury is responsible for 5% of all hospital admissions and 50% of all acute liver failures.

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