HIV & AIDS

Drug reverses signs of liver disease in people living with HIV

Researchers at the National Institutes of Health and their colleagues at Massachusetts General Hospital (MGH) in Boston report that the injectable hormone tesamorelin reduces liver fat and prevents liver fibrosis (scarring) ...

Medications

Australia has an acetaminophen poisoning problem

Most of us take paracetamol (acetaminophen) every now and again to reduce pain or fever. As far as medications go, it's one we're unlikely to associate with harm.

Health

Binge drinking may be more damaging to women

Alcohol consumption is a major cause of chronic liver disease in the United States, and binge drinking is emerging as a significant contributor to liver injury. According to the Centers for Disease Control and Prevention, ...

Medications

FDA approves drug for most deadly form of tuberculosis

(HealthDay)—A new drug has been approved as part of a powerful, three-pronged treatment regimen for the most deadly strain of tuberculosis, the U.S. Food and Drug Administration announced Wednesday.

Immunology

Gut throws cells overboard when chemical insults build up

A team of Duke researchers has discovered that cells lining the gut of zebrafish—and probably humans too—have a remarkable defense mechanism when faced with certain kinds of toxins: they hit the eject button.

Health

Drinking and your health: A reality check

(HealthDay)—The Mediterranean diet consistently tops the list of food plans that convey health benefits, and one reason many people like it is that it allows moderate amounts of red wine. But there's no definitive proof ...

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Hepatotoxicity

Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents. Certain medicinal agents when taken in overdoses and sometimes even when introduced within therapeutic ranges may injure the organ. Other chemical agents such as those used in laboratories and industries, natural chemicals (e.g. microcystins) and herbal remedies can also induce hepatotoxicity. Chemicals that cause liver injury are called hepatotoxins.

More than 900 drugs have been implicated in causing liver injury and it is the most common reason for a drug to be withdrawn from the market. Chemicals often cause subclinical injury to liver which manifests only as abnormal liver enzyme tests. Drug induced liver injury is responsible for 5% of all hospital admissions and 50% of all acute liver failures.

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