Diseases, Conditions, Syndromes

Sox9 reshapes the biliary tree in Alagille syndrome

Alagille syndrome is a rare pediatric genetic disorder that can affect the liver, heart, kidneys, blood vessels, skeleton and other tissues. One major characteristic of this condition is abnormalities in the ducts that carry ...

Health

Too much caffeine during pregnancy may damage baby's liver

Having too much caffeine during pregnancy may impair baby's liver development and increase the risk of liver disease in adulthood, according to a study published in the Journal of Endocrinology. Pregnant rats given caffeine ...

Genetics

Critical role of DHA on foetal brain development revealed

Duke-NUS researchers have found evidence that a natural form of Docosahexaenoic Acid (DHA) made by the liver called Lyso-Phosphatidyl-Choline (LPC-DHA), is critical for normal foetal and infant brain development, and that ...

Psychology & Psychiatry

Extreme stress in childhood is toxic to your DNA

The real danger of separating children from parents is not the psychological stress – it's the biological time bomb. The screaming and crying, the anguish and desolation is gut-wrenching. But the fallout pales in comparison ...

Oncology & Cancer

Liver cancer: Lipid synthesis promotes tumor formation

Lipids comprise an optimal energy source and an important cell component. Researchers from the Biozentrum of the University of Basel and from the University of Geneva have now discovered that the protein mTOR stimulates the ...

Genetics

New clues to treat Alagille syndrome from zebrafish

A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) identifies potential new therapeutic avenues for patients with Alagille syndrome. The discovery, published in Nature Communications, ...

Medical research

Researchers find that a biological 'good guy' has a dark side

A pair of Oklahoma Medical Research Foundation scientists have discovered that an enzyme previously thought only to be beneficial could, in fact, pose significant danger to developing embryos. The new research could have ...

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