The liver is crucial for the detoxification of the human body. The exposure to toxins makes it particularly prone to drug-induced injury. Cholestasis, the impairment of bile flow, is therefore a common problem of drug development ...
Mar 27, 2017
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(AP) -- A panel of cancer experts overwhelmingly backed the approval of a GlaxoSmithKline drug for a rare type of tumor, noting there are few other treatment options for patients.
Mar 20, 2012
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State and federal public health agencies often understate the scientific evidence surrounding the toxicity of per- and polyfluoroalkyl substances (PFAS) in their public communications, according to an analysis published today ...
May 11, 2022
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Researchers all over Europe are working on alternatives to animal testing that can be used to evaluate the adverse side-effects of medications. But many of these test methods still present problems. A microreactor developed ...
Feb 2, 2016
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(HealthDay)—The U.S. Food and Drug Administration has approved the orphan drug Juxtapid (lomitapide) for patients with homozygous familial hypercholesterolemia (HoFH), for use in combination with a low-fat diet and other ...
Dec 27, 2012
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Hesperos Inc., pioneers of the "human-on-a-chip" in vitro system has announced the use of its innovative multi-organ model to successfully measure the concentration and metabolism of two known cardiotoxic small molecules ...
Jul 3, 2019
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A new drug can help advanced lung cancer patients live longer and may aid in treating other kinds of cancer, researchers said Monday.
Jun 3, 2013
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Over 20 years after the fatal fialuridine trial, a study published this week in PLOS Medicine demonstrates that mice with humanized livers recapitulate the drug's toxicity. The work suggests that this mouse model should be ...
Apr 15, 2014
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As obesity rates rise in the United States, so does the incidence of liver diseases. In fact, 80 percent of obese people are believed to have non-alcoholic fatty liver disease, or NAFLD, while another related liver disorder, ...
Nov 18, 2016
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The HEMIBIO project has developed a Hepatic Microfluidic Bioreactor mimicking the structure of the human liver. The project team is confident that the new device will eventually help remove the need for testing chemicals ...
Nov 2, 2015
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