Cardiology

LDL-C still high in autosomal recessive hypercholesterolemia

(HealthDay)—For patients with autosomal recessive hypercholesterolemia (ARH), low-density lipoprotein cholesterol (LDL-C) levels remain high despite intensive treatment, according to a study published in the Jan. 23 issue ...

Cardiology

Measuring plasma PCSK9 may ID resistance to PCSK9 inhibitors

(HealthDay)—Plasma levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) may help assess apparent resistance to PCSK9 inhibitors, according to a research letter published online Nov. 28 in the Annals of Internal ...

Diabetes

Anagliptin effect on LDL in T2DM via ApoB-100 synthesis

(HealthDay)—In patients with type 2 diabetes being treated with a dipeptidyl peptidase-4 inhibitor (DPP4-I), use of anagliptin (ANA) may improve low-density lipoprotein cholesterol (LDL-C) levels, with the effect mediated, ...

Cardiology

ApoB levels more closely tied to reduced CVD events than LDL

(HealthDay)—Clinical benefit of reduced low-density lipoprotein cholesterol (LDL-C) levels may depend on the corresponding reduction in apolipoprotein B (apoB)-containing lipoprotein particles, according to a study published ...

Cardiology

Gene therapy using 'junk DNA' could lower risk for heart disease

Scientists from UCLA and the Howard Hughes Medical Institute successfully used a gene that suppresses cholesterol levels as part of a treatment to reduce plaque in mice with a disorder called familial hypercholesterolemia. ...

Cardiology

More evidence evolocumab exceeds cost-effectiveness

(HealthDay)—At its current price, the addition of evolocumab to standard therapy in patients with atherosclerotic cardiovascular disease generally exceeds accepted cost-effectiveness thresholds, according to a study published ...

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