Immunology

Protein's role in lupus development

Northwestern Medicine scientists have demonstrated that the loss of a protein called Bim in macrophages—a type of immune cell—leads to the development of lupus-like disease in mice. The findings, published in the Journal ...

Diseases, Conditions, Syndromes

Biomarker identified in systemic sclerosis predicts progression

(HealthDay)—Patients with systemic sclerosis have elevated levels of CXCL4, which predicts disease risk and progression, according to a study published online Dec. 18 in the New England Journal of Medicine.

Arthritis & Rheumatism

Canadian pediatric lupus severity varies with ethnicity

(HealthDay)—While Canadian children with systemic lupus erythematosus (SLE) differ in disease characteristics and severity by ethnicity, treatment, disease activity, and irreversible organ damage are similar across ethnic ...

Arthritis & Rheumatism

In the quest for safer treatment for systemic lupus erythematosus

The treatment of systemic lupus erythematosus has traditionally been based on glucocorticoids administered orally. Nevertheless, these drugs were known to cause serious side effects in the medium to long term. In order to ...

Genetics

Genetic variant tied to MS and systemic lupus identified

(HealthDay)—A genetic variant that is associated with both multiple sclerosis and systemic lupus erythematosus (SLE) has been identified, according to a study published online April 26 in the New England Journal of Medicine.

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