News tagged with macrophages

Related topics: immune cells · immune system · white blood cells · immune response · cells

Metabolic sensor causes granulomas to form

Granulomas are tissue nodules of immune cells that occur in diseases such as tuberculosis and sarcoidosis and can damage many organs. For the first time, a team of researchers at the Center for Pathobiochemistry and Genetics ...

Jan 16, 2017
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Missing link between hemolysis and infection found

Worldwide, millions of people suffer from hemolysis, the breakdown of red blood cells, such as those afflicted with sickle-cell disease, malaria or sepsis. These patients face an unprecedented risk of death from bacterial ...

Oct 31, 2016
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Macrophage

Macrophages (Greek: big eaters, from makros "large" + phagein "eat"; abbr. ) are white blood cells within tissues, produced by the division of monocytes. Human macrophages are about 21 micrometres in diameter. Monocytes and macrophages are phagocytes, acting in both non-specific defense (or innate immunity) as well as to help initiate specific defense mechanisms (or adaptive immunity) of vertebrate animals. Their role is to phagocytose (engulf and then digest) cellular debris and pathogens either as stationary or as mobile cells, and to stimulate lymphocytes and other immune cells to respond to the pathogen. They can be identified by specific expression of a number of proteins including CD14, CD11b, F4/80 (mice)/EMR1 (human), Lysozyme M, MAC-1/MAC-3 and CD68 by flow cytometry or immunohistochemical staining. They move by action of Amoeboid movement.

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