Big data provides clues for characterizing immunity in Japanese

Although genes are distributed widely across chromosomes, many genes related to the immune system are clustered together on human chromosome 6 in a segment called the major histocompatibility complex (MHC) region. The density ...


Team computes protein conformations for paths around autoimmunity

For years, computational biologists have sought ways to model how proteins change shape in real time. In the past decade, they've glimpsed the possibilities as new programs and powerful computers came on line, letting researchers ...


Study unveils T cell signaling process central to immune response

The immune system cells known as T cells play a central role in the body's ability to fight infections and cancer. For decades, however, details of the molecular signaling process that leads to T cell activation have remained ...


Understanding how HIV evades the immune system

Monash University (Australia) and Cardiff University (UK) researchers have come a step further in understanding how the human immunodeficiency virus (HIV) evades the immune system.


Loss of MHCI in motor neurons leads to ALS astrocyte toxicity

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a devastating progressive neurodegenerative disease that results in the death of motor neurons, the nerve cells that control muscles. Eventually, ...

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