A multi-institutional study has revealed that BRAF-positive metastatic malignant melanomas develop resistance to treatment with drugs targeting the BRAF/MEK growth pathway through a major change in metabolism. The findings, ...
Mar 8, 2013
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(Medical Xpress)—It's not unusual for cancer patients being treated with chemotherapy to complain about not being able to think clearly, connect thoughts or concentrate on daily tasks. The complaint – often referred to ...
Feb 21, 2013
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Two new mutations that collectively occur in 71 percent of malignant melanoma tumors have been discovered in what scientists call the "dark matter" of the cancer genome, where cancer-related mutations haven't been previously ...
Jan 24, 2013
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Researchers at the University of California, San Diego School of Medicine have discovered that hard-to-reach, drug-resistant leukemia stem cells (LSCs) that overexpress multiple pro-survival protein forms are sensitive – ...
Jan 17, 2013
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The human body contains immune cells programmed to fight cancer and viral infections, but they often have short lifespans and are not numerous enough to overcome attacks by particularly aggressive malignancies or invasions.
Jan 3, 2013
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(Medical Xpress)—The protein kinase Akt is a key regulator of cell growth, proliferation, metabolism, survival, and death. New work on Akt's role in cancer stem cell biology from the lab of senior author Honglin Zhou, MD, ...
Dec 20, 2012
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Researchers at the University of California, Berkeley, and the Lawrence Berkeley National Laboratory have put the squeeze—literally—on malignant mammary cells to guide them back into a normal growth pattern.
Dec 17, 2012
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(Medical Xpress)—A surprising discovery about the physical properties of cancer cells could help improve a new diagnostic approach – a liquid biopsy – that detects, measures, and evaluates cancer cells in blood.
Dec 4, 2012
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Whitehead Institute scientists report that certain molecules present in high concentrations on the surfaces of many cancer cells could be exploited to funnel lethal toxic molecules into the malignant cells. In such an approach, ...
Dec 2, 2012
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In the first broad genetic landscape mapped of a Burkitt lymphoma tumor, scientists at Duke Medicine and their collaborators identified 70 mutations, including several that had not previously been associated with cancer and ...
Nov 12, 2012
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