"Clean margins" are a goal of cancer excision surgery. If even a small piece of cancerous tissue is left behind, it increases the likelihood of a local recurrence and spread of the disease, possibly reducing overall survival ...
Jun 30, 2020
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Striking new evidence suggesting that diet and related factors early in life can boost the risk for breast cancer—totally independent of the body's production of the hormone estrogen—has been uncovered by a team of researchers ...
Sep 17, 2012
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The natural plant compound phenethyl isothiocyanate (PEITC) hinders the development of mammary tumors in a mouse model with similarities to human breast cancer progression, according to a study published August 2 in the Journal ...
Aug 2, 2012
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Unlike almost every other organ, the mammary gland does not develop until after birth. And it's unusually dynamic, shape-shifting during menstrual cycles, puberty, pregnancy, and lactation.
Dec 19, 2019
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A protein that is necessary for lactation in mammals inhibits the critical cellular transition that is an early indicator of breast cancer and metastasis, according to research conducted at the University at Buffalo and Princeton ...
Oct 24, 2012
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Cancerous tumors contain hundreds of mutations, and finding these mutations that result in uncontrollable cell growth is like finding the proverbial needle in a haystack. As difficult as this task is, it's exactly what a ...
Oct 2, 2012
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Rare stem-like tumor cells play a critical role in the spread of breast cancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before metastatic disease occurs, ...
Dec 12, 2017
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A new research paper titled "Resistance of MMTV-NeuT/ATTAC mice to anti-PD-1 immune checkpoint therapy is associated with macrophage infiltration and Wnt pathway expression" has been published in Oncotarget.
Jan 5, 2023
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Inhibitors of indoleamine 2,3-dioxygenase (IDO) are being assessed in clinical trials as a potential treatment for recurrent or refractory solid tumors. Clear genetic rationale for these trials, together with evidence that ...
Jul 19, 2012
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In experiments with mouse tissue, UC San Francisco researchers have discovered that the adaptive immune system, generally associated with fighting bacterial and viral infections, plays an active role in guiding the normal ...
Aug 27, 2015
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