Medical research

Protein discovery reinvigorates promising new therapeutic

Several years ago, a promising therapeutic using stem cell factor (SCF) emerged that could potentially treat a variety of ailments, such as ischemia, heart attack, stroke and radiation exposure. However, during clinical trials, ...

Medications

Locking leukemia's cellular escape hatch

Leukemia starts in cells that would normally develop into different types of blood cells. About 61,000 people in the U.S. are diagnosed each year, and depending on the type of leukemia and the age of the patient, five-year ...

Neuroscience

New insights on the importance of skull channels for brain health

Investigators led by a team at Massachusetts General Hospital (MGH) that previously discovered tiny channels in the skull have now found that cerebrospinal fluid (also known as "brain water") can exit the brain into the skull's ...

Surgery

New strategies for engineering stable articular cartilage

A new study assesses the effect of the gremlin-1 (GREM1) protein on the in vitro and in vivo stability of bone marrow stem cell (BMSC)-derived cartilage engineered within scaffolds. The study design and results are reported ...

Immunology

How one inflammatory disorder exacerbates another

The immune system remembers. Often this memory, primed by past encounters with threats like bacteria or viruses, is an asset. But when that memory is sparked by internal drivers, like chronic inflammation, it can prove detrimental, ...

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