Diseases, Conditions, Syndromes

Increases in IgE, eosinophils, mast cells can ID IgG4-RD

(HealthDay)—Most patients with immunoglobulin G subclass 4-related disease (IgG4-RD) have increased levels of IgE, eosinophils, and mast cells, according to research published in the September issue of Clinical Gastroenterology ...

Medical research

New insight into how immune cells are formed

In contrast to what has been previously believed, development of blood stem cells into mast cells, a type of specialised immune cell, does not depend on stem cell factor. This has been demonstrated in a new collaborative ...

Immunology

Cell senescence is regulated by innate DNA sensing

Cells in the body or in cultures eventually stop replicating. This phenomenon is called "senescence" and is triggered by shortening of telomeres, oxidative stress or genetic damage to the cells, either acute or simply due ...

Diseases, Conditions, Syndromes

Do mast cells contribute to more severe disease in dengue infection?

Why mosquito-borne dengue virus causes more severe disease in some individuals, including hemorrhagic fever with or without shock, remains controversial and researchers are focusing on the factors related to the interaction ...

Immunology

New technique removes the cause of allergic asthma

Allergies are the commonest cause of asthma. The immune system over-reacts to harmless substances such as birch or grass pollen, for example, forming immunoglobulin E antibodies (IgE). Together with the inflammatory cells ...

Oncology & Cancer

Promising approach for prognosis and treatment in mastocytosis

Systemic mastocytosis is a rare, incurable disease that affects approximately one in 10,000 people. It is a haematological tumour disease, similar to leukaemia, in which the bone marrow and other organs, such as the bowel, ...

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