Do mast cells contribute to more severe disease in dengue infection?

June 12, 2017, Mary Ann Liebert, Inc
DNA and Cell Biology is the trusted source for authoritative, peer-reviewed reporting on the latest research in the field of molecular biology. Credit: Mary Ann Liebert, Inc., publishers

Why mosquito-borne dengue virus causes more severe disease in some individuals, including hemorrhagic fever with or without shock, remains controversial and researchers are focusing on the factors related to the interaction between the virus and the host immune system, including the role of mast cells. An in-depth review of the latest research showing how mast cells can be both protective and can contribute to the most severe forms of dengue is presented in the article "Role of Mast Cells in Dengue Virus Pathogenesis," published in DNA and Cell Biology, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

Coauthors Berlin Londono-Renteria, Kansas State University, Manhattan, KS, Julio Marinez-Angarita, Instituto Nacional de Salud, Bogota, Colombia, and Andrea Troupin and Tonya Colpitts, University of South Carolina School of Medicine, Columbia, SC, study how mast cells recognize and interact with dengue virus and how mosquito saliva may affect the degranulation response of and the local immune responses during infection in human skin. The researchers provide insights on what occurs during the early stages of dengue transmission and the mechanisms involved in mast cell activation and degranulation, which can increase the permeability of the human vasculature, causing it to become leaky.

"Mast cells are best known for their roles in allergies (such as pollen or food) and, for rare people, sensitivity to the saliva injected by mosquitos during bites. In this BIT, Colpitts and co-authors demonstrate the contributions of these cells to the pathogenesis of dengue, a severe disease," says Carol Shoshkes Reiss, PhD, Editor-in-Chief of DNA and Cell Biology and Professor, Departments of Biology and Neural Science, and Global Public Health at New York University, NY. "Understanding this may lead us to new approaches to the treatment of dengue fever and . The latter secondary infection can be life-threatening."

Explore further: Researchers identify new cell that attacks dengue virus

More information: Berlin Londono-Renteria et al, Role of Mast Cells in Dengue Virus Pathogenesis, DNA and Cell Biology (2017). DOI: 10.1089/dna.2017.3765

Related Stories

Researchers identify new cell that attacks dengue virus

May 16, 2011
Mast cells, which can help the body respond to bacteria and pathogens, also apparently sound the alarm around viruses delivered by a mosquito bite, according to researchers at Duke-NUS Graduate Medical School in Singapore.

Mast cells give clues in diagnosis, treatment of dengue

April 30, 2013
A protein produced by mast cells in the immune system may predict which people infected with dengue virus will develop life-threatening complications, according to researchers at Duke Medicine and Duke-National University ...

Asthma drug against dengue to be tested in clinical trial

June 12, 2015
A drug that has been used for over 30 years as an asthma and allergy medicine is now being tested to treat symptoms of dengue fever. The National University of Singapore (NUS) and Duke-NUS Graduate Medical School Singapore ...

Dengue fever: what you need to know

February 16, 2016
An outbreak of dengue fever in Hawaii has prompted officials to declare a state of emergency on Hawaii Island.

Pre-existing immunity to dengue virus shapes Zika-specific T cell response

March 13, 2017
Although Zika and dengue are considered different virus "species," they are so closely related that the immune system treats Zika just like another version of dengue, report researchers at La Jolla Institute for Allergy and ...

Scientists discover novel vulnerabilities in dengue virus

March 30, 2017
A team of researchers from the National University of Singapore (NUS) has uncovered hidden vulnerabilities on the surface of the dengue virus. This novel discovery means that scientists can now develop strategies to target ...

Recommended for you

Drugs that stop mosquitoes catching malaria could help eradicate the disease

September 18, 2018
Researchers have identified compounds that could prevent malaria parasites from being able to infect mosquitoes, halting the spread of disease.

Vaccine opt-outs dropped slightly when California added more hurdles

September 18, 2018
In response to spiking rates of parents opting their children out of vaccinations that are required to enroll in school—and just before a huge outbreak of measles at Disneyland in 2014—California passed AB-2109. The law ...

New evidence of a preventative therapy for gout

September 17, 2018
Among patients with cardiovascular disease, it's a common complaint: a sudden, piercing pain, stiffness or tenderness in a joint that lasts for days at a time with all signs pointing to a gout attack. Gout and cardiovascular ...

"Atypical" virus discovered to be driver of certain kidney diseases

September 14, 2018
An international research team led by Wolfgang Weninger has discovered a previously unknown virus that acts as a "driver" for certain kidney diseases (interstitial nephropathy). This "atypical" virus, which the scientists ...

Flu shot rates in clinics drop as day progresses, but nudges help give them a boost

September 14, 2018
Primary care clinics experienced a significant decline in influenza vaccinations as the day progressed, researchers from Penn Medicine report in a new study published in JAMA Open Network. However, "nudging" clinical staff ...

Rare antibodies show scientists how to neutralize the many types of Ebola

September 13, 2018
Two new studies by scientists at Scripps Research are bringing Ebola virus's weaknesses into the spotlight, showing for the first time exactly how human and mouse antibodies can bind to the virus and stop infection—not ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.