Immunology

A novel painless and reliable allergy test

Although allergies are widespread, their diagnosis is complex and, depending on the type of allergy, the prospects of success with therapy are not always clear. Skin tests so far have been unpleasant, time-consuming and associated ...

Immunology

Scientists discover genetic cause of rare allergy to vibration

Scientists at the National Institutes of Health (NIH) have identified a genetic mutation responsible for a rare form of inherited hives induced by vibration, also known as vibratory urticaria. Running, hand clapping, towel ...

Immunology

Allergic immune responses help fight bacterial infections

Allergy is one of the most common diseases in Europe, it is estimated that more than 150 million Europeans suffer from recurring allergies and by 2025 this could have increased to half of the entire European population.1 ...

Immunology

Salmonella jams signals from bacteria-fighting mast cells

A protein in Salmonella inactivates mast cells—critical players in the body's fight against bacteria and other pathogens—rendering them unable to protect against bacterial spread in the body, according to researchers ...

Immunology

Under-the-tongue tablets trick immune system to fight allergies

Asha Patel knows more about what goes into your lungs than you do. Every weekday at 8 a.m., the researcher climbs onto the roof of Allegheny General Hospital, in Pittsburgh, to check a machine called a Burkard Spore Trap. ...

Medical research

New insight into how immune cells are formed

In contrast to what has been previously believed, development of blood stem cells into mast cells, a type of specialised immune cell, does not depend on stem cell factor. This has been demonstrated in a new collaborative ...

Diseases, Conditions, Syndromes

Pivotal role of TLR7 protein revealed in lung disease

Researchers have revealed that the protein Toll-like receptor 7 (TLR7), usually associated with antiviral defense in the body, surprisingly, exacerbates lung conditions such as chronic obstructive pulmonary disease (COPD), ...

Medical research

Mast cells have critical role in initializing pulmonary fibrosis

Pulmonary fibrosis is a chronic, deadly disease that affects five million people worldwide. It is irreversible, its cause is poorly understood, and it has a median survival of only about 3 years. A new study that implicates ...

Diseases, Conditions, Syndromes

Increases in IgE, eosinophils, mast cells can ID IgG4-RD

(HealthDay)—Most patients with immunoglobulin G subclass 4-related disease (IgG4-RD) have increased levels of IgE, eosinophils, and mast cells, according to research published in the September issue of Clinical Gastroenterology ...

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